Colobomatous Optic Disc

Objective: To compare the success rate of trabeculectomy with and without Mitomycin C in lowering intraocular pressure. Design: Prospective, comparative, randomized, interventional study. Duration: Two years. Place: Department of Ophthalmology, Lady Reading Hospital, Peshawar. Material and Methods :This prospective study of 100 eyes of 80 patients of glaucoma was conducted from January 2005 to December 2007 at the Department of Ophthalmology, Lady Reading Hospital, Peshawar. Patients were randomly divided into two equal groups. In group I, 50 eyes (50%) underwent trabeculectomy with intraoperative Mitomycin C while in group II, 50 (50%) eyes underwent trabeculectomy without MMC. Follow up lasted for 6 months. Results:. 62.50% of patients were male and 37.50% were female. The mean age was 52.1 years. Preoperative visual acuity ranged from 6/6 to perception of light positive (PL). Postoperative visual acuity in both groups was almost equal. The mean intraocular pressure at the end of follow-up was 12.44 mmHg with standard deviation of + 1.94 in group 1 and 13.82 mmHg with standard deviation + 4.45 in group 2. IOP >21 mmHg was found in 7 eyes (14%) in group 1 and 8 eyes (16%) in group 2. These patients were put on antiglaucoma drugs. The overall success rate of trabeculectomy with and without MMC was 86% and 84% respectively in lowering intraocular pressure which was not significantly different. (P = 0.121) Conclusion: Trabeculectomy without intraoperative MMC is as effective as trabeculectomy with MMC in uncomplicated glaucoma.